ea0019p176 | Endocrine tumours and neoplasia | SFEBES2009
Kalhan A
, Vazquez M
, Jasani B
, Stott J
, Neal J
, Gharibi B
, Kidd M
, Modlin I
, Pfragner R
, Rees D
, Ham J
Neuroendocrine tumors (NETs) of GI tract are a heterogeneous group of neoplasms that secrete peptides and amines. Small bowel NETs originate from enterochromaffin (EC) cells and secrete chromogranin A (CgA) and serotonin (5-HT). NETs are highly vascular, a reflection of increased tumour related angiogenesis. Adenosine, the major regulator of angiogenesis, is released by enhanced degradation of ATP, during cellular stress, damage and hypoxia.Aims: Aims of...